Which mutation is harmful to the organism

A, a mutation allowing moths to camouflage better on blackened tree bark

B, a mutation making staphylococcus aureus resistant to the antibiotic methicillin

C, a mutation inhibiting human immunodeficiency virus from attaching to and entering the cell

D, a mutation causing uncontrolled cell division

E, a mutation giving plant leaves a bitter taste to discourage herbivores from eating them