elishalieblein9625 elishalieblein9625

17-10-2019
Biology

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What is the main genetic defect that is associated with chronic myeloid leukaemia (CML)?

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prinbunsongsikul prinbunsongsikul

17-10-2019

Answer:

Blood-cell cancer that begins in the bone marrow.

Explanation:

Chronic myeloid leukemia is caused by a rearrangement (translocation) of genetic material between chromosome 9 and 22. This translocation, written as t(9;22), fuses part of the ABL1 gene from chromosome 9 with part of the BCR gene from chromosome 22, creating an abnormal fusion gene called BCR-ABL1.

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