Since enzymes' shape is mostly determined by intermolecular forces, which are very ______-sensitive, altering the _____ or _____ the enzyme easily disrupts the intermolecular forces and causes the enzyme to _____. 
 
a) Temperature - pH - Substrate - Denature 
 
b) Pressure - Concentration - Inhibitor - Catalyze 
 
c) Light - Volume - Reactant - Synthesize 
 
d) Humidity - Solubility - Activator - Bind